在日本从猪中分离出来的抗甲素黄金葡萄球菌的流行率和遗传特征
Michiko Kawanishi1, Mari Matsuda1, Hitoshi Abo1
1Veterinary AMR Center, National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo 185-8511, Japan.
Antibiotics (Basel, Switzerland)
|February 23, 2024
概括
在日本的猪屠宰场中,与畜牧业相关的甲素耐药黄金葡萄球菌 (LA-MRSA) 正在增加. 猪菌株在遗传上与人类菌株不同,这表明当前风险有限,但强调需要谨慎使用抗微生物和.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 一个健康 一个健康
背景情况:
- 与畜牧业相关的甲素耐药黄金葡萄球菌 (LA-MRSA) 构成了越来越严重的公共卫生问题.
- 食品生产动物中LA-MRSA的流行和特征需要持续监测.
研究的目的:
- 调查2018年至2022年在日本猪屠宰场中LA-MRSA的流行率和遗传特征.
- 分析抗微生物敏感性,并确定LA-MRSA分离物中的耐药基因.
- 为了比较来自猪的LA-MRSA与人类菌株.
主要方法:
- 对LA-MRSA分离物的全基因组测序.
- 抗微生物敏感性测试.
- 使用单核酸多形态 (SNP) 的基因分析.
主要成果:
- 在日本的猪屠宰场中,在五年内观察到LA-MRSA患病率的逐渐上升趋势.
- ST398/t034和ST5/t002是占主导地位的菌株,表现出明显的抗微生物耐药性概况,并携带特定的耐药性基因,包括ST398.8中普遍存在的耐药性基因.
- 来自猪的ST398和ST5菌株形成了一个与人类MRSA不同的集群,缺乏关键的免疫逃避基因.
结论:
- 多种药物和耐药性共同选择可能会导致猪中的LA-MRSA持久性.
- 由于遗传差异,日本的猪源LA-MRSA目前对人类临床传播的风险较低.
- 谨慎使用抗微生物和,以及严格的卫生,对于防止LA-MRSA传播至关重要.
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