在有意识的镇静中醒着的骨切割:A2激动剂的作用
Antonio Izzi1, Giuseppe Mincolelli1, Grazia D'Onofrio2
1UOC of Anesthesia and Resuscitation II, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy.
Brain sciences
|February 23, 2024
概括
这项研究强调了将德克斯梅德托米丁等α2-激动剂与雷米芬坦尼尔结合在清醒时进行骨切割 (AC) 的麻醉的有效性. 协同方法确保了患者的舒适性和程序的成功,副作用最小.
科学领域:
- 麻醉学 麻醉学
- 神经外科 神经外科
背景情况:
- 醒着的骨切除术 (AC) 经常使用α2-agonists和remifentanil用于监控麻醉护理.
- 德克斯梅德托米丁和克洛尼丁是关键的α2-激动剂,与雷米芬坦尼尔一起使用.
- 评估alpha2-agonists在AC麻醉管理中的作用至关重要.
研究的目的:
- 为了阐明 alfa2-agonists 在清醒时切除术中发挥的关键作用.
- 评估在AC的麻醉治疗中存在或没有并发症.
主要方法:
- 研究了一组42名在意大利三个中心接受AC治疗的患者.
- 使用连续静脉注射的德克斯梅德托米丁和雷米芬坦尼尔实现了疼痛镇静.
- 手术前的前期治疗涉及肌肉内克洛尼丁 (2μg/kg).
主要成果:
- 没有报告任何手术内或术后显著副作用.
- 手术的平均持续时间为240±62分钟.
- 报告的满意度很高,有86%的患者和93%的外科医生表示完全满意.
结论:
- 阿片类药物和α2-激动剂的组合对于成功的清醒骨切割手术至关重要.
- 这种协同麻醉方法有助于患者的舒适性和安全性.
- 这项研究强调了α2-agonists在现代神经麻醉中的重要性.
更多相关视频
08:16Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
2.2K
10:19Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
Published on: March 31, 2016
8.1K
相关概念视频
Stages of General Anesthesia
444
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
444
General Anesthesia: Overview
219
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
219
Parenteral Anesthetics: Overview
125
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
125
Subconsciousness and No Awareness
242
The concept of subconscious awareness refers to the processing of information below the level of conscious thought, which significantly influences both behaviors and decisions. It is also known as waking subconscious awareness. This complex level of cognition operates without the direct awareness of the individual, facilitating rapid and simultaneous handling of multiple information streams.
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
An illustrative example of subconscious processing is its role in problem-solving. Often, individuals...
242
