帕金森病和非典型帕金森综合征中的冲动控制障碍 - 有区别吗?
Mateusz Toś1, Anna Grażyńska2, Sofija Antoniuk3
1Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland.
Brain sciences
|February 23, 2024
概括
冲动控制障碍 (ICD) 在帕金森病 (PD) 和非典型帕金森症 (APS) 中经常发生. 像多巴胺疗法一样,PD中ICD的风险因素在APS中并不完全反映,特别是在渐进性超核性麻 (PSP) 中.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 冲动控制障碍 (ICD) 的特点是情绪和行为的自我控制受损,表现为博,过度性行为,暴饮暴食和强迫性购买.
- ICD是帕金森病 (PD) 中公认的非运动性症状,通常与多巴胺治疗 (DRT) 相关,特别是多巴胺激动剂 (DA).
- 在非典型帕金森症 (APS),包括渐进性超核性 (PSP) 和多重系统缩 (MSA) 中,很少报告ICD,对相关风险因素的理解有限,尽管有证据表明PSP的冲动性增加.
研究的目的:
- 为了确定与PD患者相比,APS患者的个人ICD的频率.
- 识别潜在的风险因素,有助于发展的ICDs在APS.
主要方法:
- 一项前性研究,涉及2020年至2023年期间的185名PD患者和35名APS患者 (27名PSP,9名MSA).
- 使用帕金森病冲动-强迫性障碍问卷 (QUIP) 评估ICD.
- 评估疾病进展,抑郁症严重程度,认知障碍,并收集人口统计和治疗数据.
主要成果:
- ICDs存在于23.39%的PD患者和18.52%的PSP患者中,PD,MSA和PSP的频率相似 (p = 0.4696).
- 在PD中,更高的DA和L-dopa剂量,更长的疾病持续时间和运动并发症与增加的ICD发病率有关.
- 在APS患者中没有发现对ICD发病率的显著治疗效应.
结论:
- ICD在PD和APS中都是常见的,发生频率相似.
- 已确定的PD风险因素对于ICD,如DRT和疾病持续时间,并不完全适用于APS.
- 在PSP中,除了DRT之外的其他机制,可能涉及神经元循环和神经递质缺陷,可能有助于ICD的发展,需要进一步研究.
关键词:
帕金森病是帕金森氏症的一种疾病.吃得过多,吃得过多,吃得过多.强迫性购买 强迫性购买多巴胺激动剂是多巴胺激动剂.过度性欲是一种过度性欲.冲动控制障碍 冲动控制障碍冲动性是一种冲动性.多个系统缩.病态博是一种病态的博.渐进性的超核性麻.更多相关视频
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