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超化,高度水溶性多酸作为潜在的磁共振成像 (MRI) 对比剂

Paul Strasser¹, Verena Schinegger¹, Joachim Friske²

¹Institute of Polymer Chemistry, Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz, Austria.

Journal of functional biomaterials

|February 23, 2024

概括

新的大分子载体增强了-19磁共振成像 (MRI) 的对比度. 这些新型药物为定量疾病标志物检测提供了更好的水溶性和成像效率.

科学领域:

生物医学成像技术生物医学成像技术
材料科学材料科学材料科学
聚合物化学聚合物化学

背景情况:

-19磁共振成像 (F-MRI) 提供了定量疾病标志物成像,因为可以忽略的背景信号.
目前的基于高碳 (PFC) 的对比剂具有局限性,包括低纵向放松率和成像效率.

研究的目的:

设计和合成用于增强F-MRI的新型宏分子对比剂.
为了达到高核密度,足够的流动性,以及在对比剂中优异的水溶性.

主要方法:

超聚酸聚合物 (PPz) 聚合物被用作-19的来源.
用PPz聚合物修改了甲硫酸盐 (MESNa),以提高水溶性.
进行F-MRI以评估与对照组相比的信号增强.

主要成果:

合成的宏分子载体表现出极好的水溶性 (>360 mg/mL).
在使用这些新型载体的F-MRI中观察到显著的信号增强.
性能优于非增强环境,与水性三酸 (TFA) 阳性对照相比较.

结论:

基于改性多素的新型水溶性宏分子载体对F-MRI具有前景.
这些药物为开发用于定量疾病成像的先进MRI对比剂提供了潜在的平台.

关键词:

在19F-MRI中.可生物降解的聚合物.没有加多的对比剂.聚酸是一种多酸.超化聚合物的超化聚合物.

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