开发一种定量数字尿液分析工具,用于检测亚酸盐,蛋白质,肌素和pH值
Vince S Siu1, Minhua Lu1, Kuan Yu Hsieh1,2,3
1IBM T.J. Watson Research Center, Yorktown Heights, NY 10598, USA.
Biosensors
|February 23, 2024
概括
一个新的便携式色度计使得成本效益低廉的,点的护理尿液分析酸盐,蛋白质和肌素. 该设备通过计算尿蛋白与肌素 (UPC) 的比率来帮助早期检测尿路感染和脏健康管理.
科学领域:
- 生物医学工程 生物医学工程
- 分析化学 分析化学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 尿路感染 (UTI) 需要早期检测酸盐.
- 脏健康管理需要定期监测尿蛋白与肌素 (UPC) 的比例.
- 当前的诊断方法往往缺乏医疗服务点的可访问性.
研究的目的:
- 开发一个具有成本效益的,便携式色度计用于定量尿液分析.
- 为了能够在护理地点检测亚酸盐,蛋白质和肌素.
- 为了方便计算尿蛋白与肌素 (UPC) 的比率.
主要方法:
- 使用可访问组件开发一个便携式,基于传输的色度仪.
- 通过蓝牙通过智能手机控制操作,以方便用户.
- 在各种尿液矩阵中测试了对灵敏度,特异性和稳定性的色度检测策略.
主要成果:
- 成功量化检测了亚酸盐 (6.25-200μM),蛋白质 (2-1024 mg/dL),肌素 (2-1024 mg/dL) 和pH (5.0-8.0) 的含量.
- 精确计算尿蛋白与肌素 (UPC) 的比率在护理点.
- 在数据存储 (本地/云) 和安全的云连接方面证明了多功能性.
结论:
- 开发的色度仪为护理点尿液分析提供了重大进步.
- 能够方便地监测脏健康状况和早期检测尿路感染.
- 通过可访问的诊断来降低医疗保健成本和改善患者管理的潜力.
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