MRAP2 抑制β-阿雷斯-2 招募到普罗基尼提辛受体2
Roberta Lattanzi1, Ida Casella2, Maria Rosaria Fullone3
1Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Current issues in molecular biology
|February 23, 2024
概括
黑色皮质素受体辅助蛋白2 (MRAP2) 调节了普基尼提辛受体2 (PKR2) 信号传递. 这项研究探讨了MRAP2项目.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 神经科学是一个神经科学.
背景情况:
- 黑色皮质素受体辅助蛋白2 (MRAP2) 是一种与G蛋白合受体 (GPCRs) 相互作用的膜蛋白,调节能量稳态.
- 由PK1和PK2准的Prokineticin受体 (PKRs) 是参与能量平衡的关键GPCRs,并由MRAP2.2调节.
研究的目的:
- 调查MRAP2在调节PKR2-介导β-arrestin-2招募和下游信号通路中的作用.
- 了解MRAP2如何影响PK2的厌食性影响.
主要方法:
- 研究了MRAP2与PKR2.2的相互作用.
- 在MRAP2.2的存在和缺席下评估β-arrestin-2对PKR2的招募.
- 分析了β-止素介导的信号传输.
主要成果:
- 与PKR1和PKR2结合的MRAP2抑制了PK2.2的厌氧效应.
- MRAP2 影响 PKR2 诱导的 β-arrestin-2 招募和信号通路.
- 在PK2刺激后,PKR2与各种G蛋白亚型结合,并在没有受体内化的情况下招募β-arrestin.
结论:
- MRAP2在调节PKR2信号传递方面发挥着重要作用,影响能量恒温.
- 研究结果表明,MRAP2和PKR通路是肥胖和相关代谢障碍的潜在治疗点.
相关概念视频
Microtubule Associated Proteins (MAPs)
4.3K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
4.3K
PI3K/mTOR/AKT Signaling Pathway
3.6K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.6K
MAPK Signaling Cascades
5.5K
Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.5K
GPCR Desensitization
6.0K
G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
6.0K
The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
Enzyme-linked Receptors
78.4K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
78.4K


