意大利儿童和青少年的阿波蛋白B和脂质谱
Francesco Martino1, Tarcisio Niglio2, Eliana Martino1
1Department of Internal Medicine, Anesthesiology and Cardiovascular Science, Sapienza University of Rome, I-00161 Rome, Italy.
Journal of cardiovascular development and disease
|February 23, 2024
概括
在儿童和青少年中,Apolipoprotein B (ApoB) 水平随着总胆固醇 (TC) 和LDL胆固醇 (LDL-C) 的增加而增加. ApoB是识别年轻人的高脂血症的一个有价值的标志物.
科学领域:
- 儿科 儿科 儿科
- 生物化学 生物化学
- 预防心血管疾病 预防心血管疾病
背景情况:
- 从童年开始,预防心血管疾病至关重要.
- 脂蛋白B (ApoB) 是一种新兴的脂蛋白的生物标志物.
- 儿童和青少年的ApoB评估对于早期发现心血管风险至关重要.
研究的目的:
- 为了评估意大利高脂血症儿童和青少年的阿波利波蛋白B (ApoB) 水平.
- 调查小儿科患者的ApoB水平和脂质配置文件之间的关系.
- 评估ApoB在识别18岁以下个体的高脂血症方面的实用性.
主要方法:
- 对1877名儿童和青少年 (0-18岁) 的回顾性分析.
- 包括脂质概况,ApoB,以及疑似高脂血症病例的人类学数据.
- 排除患有二次性高脂血症或肥胖症的患者;使用Epi-Info 7分析的数据.
主要成果:
- 平均ApoB水平逐渐从65升至110毫克/分升,随着总胆固醇 (TC) 的上升.
- 在所有年龄小组和性别中发现了ApoB和TC/LDL-C之间的显著相关性.
- 在最年轻的年龄组 (0-5岁) 观察到最高的ApoB,TC和LDL-C水平.
结论:
- 阿波蛋白B (ApoB) 水平与总胆固醇 (TC) 和LDL胆固醇 (LDL-C) 有积极的相关性.
- ApoB 作为一个有效的参数,用于区分正常和高脂血症儿科患者.
- 在正常人群中,血清ApoB水平约为70 mg/dL,在超脂症患者中约为100 mg/dL.
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