围 Carotid 脂肪组织和动脉样硬化在心动脉分支处
Joana Ferreira1,2,3,4, Adhemar Longatto-Filho3,4,5,6, Ana Dionísio7
1Vascular Surgery Department, Physiology and Surgery, University Hospital Centre of São João, 4200-319 Porto, Portugal.
Journal of cardiovascular development and disease
|February 23, 2024
概括
通过外介质厚度 (EMT) 测量周周心脏脂肪组织的数量与心脏动脉样硬化有关. 较高的EMT表示更严重的斑块,并与急性中风事件有关.
科学领域:
- 血管医学 血管医学
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 易受伤害的动脉斑块导致20%的缺血性中风.
- 识别可能成为症状的无症状斑块至关重要但具有挑战性.
- 周周质脂肪组织可以提供关于斑块脆弱性的见解.
研究的目的:
- 在患有外周动脉疾病 (PAD) 的患者中,研究围心血管脂肪组织 (通过外介质厚度估计,EMT) 和心血管样特征在心血管分支之间的关联.
主要方法:
- 一项观察性,前性,单中心的纵向研究,涉及177名患有PAD的患者.
- 冠状动脉多普勒超声波用于测量EMT,内心介质厚度 (IMT),斑块存在,斑块区域和冠状动脉狭窄.
- 超介质厚度 (EMT) 在两侧测量并平均,特别注意与动脉狭窄相关的ipsilateral EMT.
主要成果:
- 较高的平均EMT与动脉斑块 (p=0.001),IMT (p=0.007-0.010) 和较大的斑块区域 (p=0.004-0.036) 的存在有关.
- 较高的ipsilateral EMT与显著的左动脉狭窄症 (≥70%) (p=0.009) 和"急性罪祸首"动脉狭窄症 (p=0.009-0.015) 有关.
- 在与"急性罪祸首"狭窄症相关的神经事件发生六个月后,ipsilateral EMT 减少 (p=0.036).
结论:
- 由EMT量化的周周心动脉脂肪组织与心动脉动脉样硬化有关.
- 平均EMT反映了慢性动脉样硬化负担,而ipsilateralEMT与急性斑块事件有关.
- EMT可以作为一种潜在的成像生物标志物,用于识别易受伤害的动脉斑块.
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