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Updated: Jun 20, 2026

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内皮原生细胞中的线粒体功能障碍:从血管内皮细胞解开洞察力

Azra Kulovic-Sissawo1,2, Carolina Tocantins1,2,3,4,5, Mariana S Diniz1,2,3,4,5

  • 1Perinatal Research Laboratory, Department of Obstetrics and Gynaecology, Medical University of Graz, Auenbruggerplatz 14, 8036 Graz, Austria.

Biology
|February 23, 2024
PubMed
概括

心血管风险因素会损害内皮原生细胞 (EPC) 中的线粒体功能,导致内皮功能障碍. 在EPC中准线粒体健康可能为血管疾病提供治疗策略.

关键词:
心血管疾病心血管疾病心血管疾病的危险因素内皮质功能障碍 在内皮质功能障碍体前代细胞是内皮前代细胞.线粒体功能障碍 线粒体功能障碍神经退行性疾病的神经退行性疾病有活性氧物种的反应性氧物种.

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Mitochondrial Precursor Proteins01:39

Mitochondrial Precursor Proteins

Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
Most of the mitochondrial precursors...