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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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sTREM2通过MAPK-JNK信号通路在髓衍生的细胞模型中不同影响细胞因子表达

Ryan Arsenault1,2, Steven Marshall2, Patrick Salois1

  • 1Human Health Therapeutics Research Centre, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada.

Biology
|February 23, 2024
PubMed
概括

可溶性TREM2 (sTREM2) 通过调节髓状细胞中的炎症性细胞因子表达来影响先天免疫反应. 这项研究显示,sTREM2激活了MAPK-JNK信号传递和NLRP3炎症酶通路.

关键词:
MAPKJNK的信号传输方式在NLRP3炎症酶体中,NLRP3炎症在THP-1细胞中.在TREM2中,我们可以使用TREM2.细胞因子表达的表达方式炎症反应是一种炎症反应.天生的免疫反应.巨细胞是一个巨细胞.单细胞 (Monocytes) 是一种单细胞.可溶性TREM2 (sTREM2) 是一种可溶性TREM2

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