帕沃病毒B19感染和怀孕:对当前知识的审查
Fernanda Parciasepe Dittmer1, Clara de Moura Guimarães1, Alberto Borges Peixoto2,3
1Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo 04023-062, SP, Brazil.
Journal of personalized medicine
|February 23, 2024
概括
帕尔沃病毒B19感染可以导致严重的胎儿贫血和孕妇的水. 管理包括监测胎儿贫血,必要时用多普勒超声波和子宫内输血.
科学领域:
- 病毒学 病毒学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 帕尔沃病毒B19是一种来自帕尔沃病毒家族的人类病原性病毒.
- 传染是通过呼吸道分泌物,接触,输血或移植发生的.
- 虽然往往无症状或轻度 (感染性红斑),但可能出现严重的症状,如贫血,血栓缩和中性质减退.
研究的目的:
- 概述在怀孕期间感染帕尔沃病毒B19的风险和管理.
- 详细说明母亲和胎儿感染的诊断方法.
- 描述目前胎儿贫血的治疗策略.
主要方法:
- 母亲诊断包括IgG和IgM抗体测试.
- 胎儿诊断使用PCR通过羊膜切割.
- 胎儿贫血监测采用中脑动脉 (MCA) 多普勒峰值缩速度 (PVS-MCA).
主要成果:
- 非免疫性孕妇面临胎儿感染的风险,在早期的三个月有更高的并发症.
- 受感染的胎儿可能会患上严重的贫血,水或流产.
- 对于检测胎儿贫血来说,PVS-MCA 多普勒测试非常重要.
结论:
- 目前没有针对帕尔沃病毒B19.9的疫苗.
- 管理重点是通过带状细胞切割对被诊断为胎儿贫血的子宫内输血.
- 预防策略强调减少孕妇的暴露.
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