在过去的五十年中报告的来自真菌的奥斯型美罗特类物质:一篇评论
Jia-Li He1,2, Chang-Jing Chen1, Yong-Hong Liu2
1Ministry of Education Key Laboratory for Ecology of Tropical Islands, College of Life Sciences, Hainan Normal University, Haikou 571158, China.
Journal of fungi (Basel, Switzerland)
|February 23, 2024
概括
这篇综述总结了来自真菌的104种奥斯型美基 (ATMT),详细介绍了它们的隔离,结构和生物活性,如杀虫剂和抗炎作用. 青和阿斯伯吉勒斯是这些化合物的关键真菌生产者.
科学领域:
- 自然产品化学 自然产品化学
- 菌类学 菌类学是指菌类学.
- 菌生物多样性 菌生物多样性
背景情况:
- 奥斯是一种多胺菌毒素,于1976年首次分离出来.
- 从那时起,不断发现新的奥斯型美类物质 (ATMT).
- ATMT是具有多样化化学结构的真菌二次代谢产物.
研究的目的:
- 提供从1976年到2023年报告的新型ATMT的全面摘要.
- 审查ATMT的隔离,化学结构和生物活动.
- 要突出与ATMT生产相关的真菌生物多样性和分类学.
主要方法:
- 从1976年10月到2023年1月的科学出版物的文献综述.
- 汇编和分析了104个新型ATMT的数据.
- 根据生产真菌属和报告的生物活性对ATMT进行分类.
主要成果:
- 在5种真菌属中发现了104种新的ATMT.
- 子和阿斯伯吉洛斯是主要的生产者,分别占ATMT的63.5%和30.8%.
- 大约26.9%的ATMT表现出显著的生物活性 (杀虫剂,抗炎,细胞毒性,抗菌,PTP1B抑制剂).
结论:
- ATMT代表了一种具有显著生物活性潜力的各种类型的真菌代谢物.
- 青和阿斯伯吉勒斯是新型ATMT发现的关键来源.
- 对ATMT及其产生的真菌的进一步研究可以导致新的治疗和工业应用.
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