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自身免疫性甲状腺疾病对病毒性肺炎发展的影响,包括COVID-19:一个双样本的门德尔随机化研究
Kexin Yi1, Mingjie Tian2, Xue Li1
1School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
自身免疫性甲状腺疾病 (AITD) 增加了病毒性肺炎和COVID-19严重程度的风险. 对AITD的遗传倾向与这些呼吸道感染中更高的易感性和更糟糕的结果有因果关系.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 遗传学 遗传学 是一个
背景情况:
- 甲状腺功能与包括COVID-19在内的病毒性肺炎之间的关系是复杂的,并未完全理解.
- 以前的研究表明可能存在联系,但缺乏因果关系的证据.
研究的目的:
- 使用门德尔随机化研究甲状腺疾病和甲状腺激素水平与病毒性肺炎和COVID-19之间的因果关系.
- 为了澄清遗传倾向在甲状腺疾病中的作用,涉及呼吸道病毒感染.
主要方法:
- 使用双样本孟德尔随机化 (MR) 分析,对来自七项全基因组关联研究 (GWAS) 的总结统计数据进行分析.
- 采用逆变量权衡 (IVW) 作为主要方法,并补充了加权中位数,加权模式,MR-Egger和MR-PRESSO.
- 进行了敏感性分析,包括Cochran的Q测试,MR-Egger拦截和MR-PRESSO以确保稳定性.
主要成果:
- 发现自身免疫性甲状腺疾病 (AITD) 的遗传倾向和对病毒性肺炎的敏感性增加之间存在显著的因果关系 (OR: 1.096,95% CI: 1.022-1.176).
- AITD还显示,与COVID-19的高度易感性和严重性存在因果关系,包括住院和严重疾病.
- 在TSH,FT4,亚临床甲状腺功能低下症或亚临床甲状腺功能增强症和病毒性肺炎或COVID-19结局之间没有观察到显著的因果关系.
结论:
- 这项研究提供了强有力的证据,证明AITD对病毒性肺炎发展的因果关系.
- AITD与COVID-19的易感性和严重性增加有因果关系.
- 甲状腺激素水平和亚临床甲状腺功能障碍似乎对病毒性肺炎或COVID-19的结果没有因果关系.
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