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相关概念视频

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

939
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
939
Development of Immunocompetence01:22

Development of Immunocompetence

307
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Immunocytochemistry and Immunohistochemistry01:22

Immunocytochemistry and Immunohistochemistry

11.3K
Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
These...
11.3K
Transcytosis of IgG01:15

Transcytosis of IgG

2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K

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相关实验视频

Updated: Jul 2, 2025

Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis
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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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在常见变异性免疫缺陷中IgD+IgM-B细胞

Taissa de M Kasahara1, Sudhir Gupta2

  • 1Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro 21941-853, Brazil.

Pathogens (Basel, Switzerland)
|February 23, 2024
PubMed
概括

常见的可变免疫缺陷 (CVID) 涉及免疫失调. 在CVID患者中,IgD+记忆B细胞可能会导致过敏状况,而阳性IgD+B细胞似乎不受影响.

关键词:
B 细胞细胞B 细胞细胞在CVID中,我们可以看到.在 IgD 的情况下,IgD 是呼吸道过敏疾病 呼吸道过敏疾病这是一个宽容的宽容度.

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Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells
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Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells
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相关实验视频

Last Updated: Jul 2, 2025

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Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells
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科学领域:

  • 免疫学 免疫学 免疫学
  • B细胞生物学B细胞生物学

背景情况:

  • 常见的可变免疫缺陷 (CVID) 是成年人的一次性低血糖球蛋白血症,经常导致感染和自身免疫并发症.
  • 在CVID中免疫失调机制尚未完全理解.
  • 免疫球蛋白D (IgD) 在B细胞耐受性和粘膜免疫力中起作用.

研究的目的:

  • 在CVID患者中研究IgD表达B细胞的频率和功能.
  • 探索IgD+B细胞在CVID相关的自身免疫性疾病和过敏状况中的潜在作用.

主要方法:

  • 流细胞计用于分析IgD+原始和记忆B细胞种群.
  • 评估了阳性IgD+IgM-CD27-B细胞的增殖反应.
  • 患有和没有自身免疫性疾病的CVID患者与健康对照者进行了比较.

主要成果:

  • 在CVID患者和对照人群之间,无效IgD+IgM-CD27-B细胞中没有发现显著差异.
  • 特别是在患有过敏性鼻炎或喘的CVID患者中观察到较高的IgD+IgM-记忆B细胞百分比.

结论:

  • 在研究的CVID队列中,无能IgD+IgM-CD27-B细胞似乎没有受到损害.
  • 在CVID患者中,IgD+IgM-记忆B细胞可能与过敏性鼻炎和喘的免疫病原发生有关.
  • 需要进一步的研究来阐明IgD+IgM-记忆B细胞在CVID相关过敏中所起的确切作用.