烟草吸烟是成年人结核病的危险因素:流行病学和疾病发病的各个方面
Charles Feldman1, Annette J Theron2, Moloko C Cholo2
1Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, York Road, Parktown, Johannesburg 2193, South Africa.
Pathogens (Basel, Switzerland)
|February 23, 2024
概括
吸烟会显著增加结核病 (TB) 的风险和严重程度,因为它会损害免疫系统,并促进抗生素耐药性. 结核病控制计划应解决戒烟问题,以减少疾病负担.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 毒理学 毒理学 毒理学
背景情况:
- 结核病 (TB) 仍然是全球传染病死亡的主要原因,在2022年有1060万例病例和130万例死亡.
- 长期以来,人们观察到吸烟与结核病之间存在着长期的联系,越来越多的证据支持吸烟作为一个重要的风险因素.
研究的目的:
- 审查吸烟和结核之间的多方面的关系.
- 探索吸烟对结核病原,免疫反应和抗生素耐药性的影响.
主要方法:
- 对流行病学,临床和实验室研究的审查.
- 对吸烟对膜巨细胞功能和Mycobacterium结核病生存率的影响的分析.
- 研究吸烟引起的细菌毒性和抗生素敏感性的变化.
主要成果:
- 主动吸烟和被动吸烟是结核病感染,疾病进展和死亡率的独立风险因素.
- 吸烟抑制了膜巨细胞的关键抗菌机制.
- 香烟烟雾通过生物膜形成,增强排泄活动和基因修改促进结核病抗生素耐药性.
结论:
- 戒烟是控制结核病的关键,但仍未充分利用的干预措施.
- 了解吸烟的传染机制对于制定有效的结核病策略和打击抗生素耐药性至关重要.
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