单层涂层的配方和优化,用于将布塞索尼德颗粒向下降的结肠
Fatemeh Soltani1, Hossein Kamali2, Abbas Akhgari1,2
1Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical development and technology
|February 23, 2024
概括
这项研究开发了一种优化的单层涂层,用于布索尼德颗粒,增强药物输送到下降结肠左侧结肠炎治疗. 这种新型涂层可以确保有针对性的布德索尼德释放,改善患者的服从性和治疗结果.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 结肠直肠治疗方法
背景情况:
- 目前的布德索尼德配方不足以治疗左侧结肠炎.
- 患者坚持长期使用大肠炎的浸泡剂是令人担忧的.
- 向下垂结肠的向输送对于有效治疗左侧结肠炎至关重要.
研究的目的:
- 开发和优化布索尼德颗粒的单层涂层.
- 为了实现目标的布索尼德释放,特别是在下降结肠.
- 为了提高治疗疗效和患者对左侧结肠炎的遵守性.
主要方法:
- 通过挤出球化制备的布德索尼德颗粒.
- 涂料配方优化使用响应表面方法与pH和时间依赖的Eudragits.
- 在各种pH值 (1.2,6.5,6.8,7.2) 和模拟胃肠道条件下进行溶解测试.
主要成果:
- 确定了一个最佳的涂层组成 (48%Eudragit S,12%Eudragit L,40%RS在10%的涂层水平).
- 涂层颗粒表现出均的厚度和pH/时间依赖的布德索尼德释放.
- 在结肠条件下观察到9小时的零顺序释放动力学,表明持续释放.
结论:
- 一个优化的单层涂层有效地准了budesonide向下降结肠的输送.
- pH值和时间依赖的涂层增强了药物释放动力学,显示了持续递送的前景.
- 这种方法为治疗左侧结肠炎的阴囊提供了可行的替代方案.
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