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在学龄前儿童人口中对土壤传播的虫感染的监测:行为和免疫反应的变化是否会影响流行率?

Riyadi Adrizain¹, Monika Verena Nagari², Hadyana Sukandar³

¹Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.

Tropical medicine and infectious disease

|February 23, 2024

概括

在儿童中,土壤传播的虫感染与衰老有关. 较低的维生素D (25~OH) D和特定的白内素 (IL-5,IL-13) 水平显著增加感染风险,特别是在缩的儿童中.

科学领域:

公共卫生公共卫生
热带医学热带医学
儿科儿科儿科

背景情况:

土壤传播的虫 (STHs) 是一个主要的全球健康问题,特别影响儿童并导致衰老.
免疫反应,包括涉及IL-5和IL-13的免疫反应,在STH感染及其长期后果 (如生长障碍) 中发挥作用.

研究的目的:

调查25~OH) D,IL-5,IL-13水平与24-59个月龄儿童的STH感染患病率之间的关联.
在印度尼西亚儿童的发展迟缓背景下探索这些关系.

主要方法:

一项相关的,横截面研究,涉及694名儿童 (401名缩,293名正常身高) 在印度尼西亚班敦地区.
收集有关STH感染,25(OH) D,IL-5和IL-13水平的数据.

主要成果:

发育迟缓儿童的STH感染率为5.7%,正常身高儿童的STH感染率为3.4% (p=0.156).
患有低25-OH-D,IL-5和IL-13水平的儿童患STH感染的概率是6.93至16.71倍.
发现IL-5,IL-13,环境因素和缩儿童的STH感染流行率之间存在显著的关系.

结论:

维生素D和特定的白内素与幼儿的STH感染风险有关.
研究结果强调了免疫因素,营养状况 (维生素D) 和虫感染在儿童衰老中的相互作用.

关键词:

25 (((OH) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D)它们有IL-13和IL-13.在IL-5中,IL-5是最常见的.感染STH的感染.发育不良发育不良缩发育不良

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