意想不到的Amanita phalloides-诱导的血液毒性-从回顾性研究的结果
Miranda Visser1, Willemien F J Hof1, Astrid M Broek1
1Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen (UMCG), 9713 GZ Groningen, The Netherlands.
Toxins
|February 23, 2024
概括
阿曼尼塔法洛伊德 (Amanita phalloides) 中毒会导致血液参数发生显著变化,包括血红蛋白和血小板的降低. 这种血液毒性在患有急性肝衰竭 (ALF) 的患者中更为明显.
科学领域:
- 毒理学 毒理学 毒理学
- 血液学 血液学 血液学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 阿曼尼塔法洛伊德 (Amanita phalloides) 中毒是一种严重的健康问题,死亡率高 (10-40%).
- 中毒通常会导致严重的肝脏和脏毒性.
- 阿曼尼塔化物对血液学参数的影响仍未得到充分研究.
研究的目的:
- 系统地评估Amanita phalloides中毒对血液学参数的影响.
- 评估血液学变化与中毒严重程度之间的相关性,特别是在急性肝衰竭 (ALF) 的情况下.
主要方法:
- 在1994年至2022年期间,对28名疑似Amanita phalloides中毒的患者进行了回顾性分析,这些患者在格罗宁根大学医学中心 (UMCG) 住院治疗.
- 收集人口统计数据,肝脏,脏和血液参数,治疗细节和结果.
- 使用毒素严重性评分 (PSS) 进行严重性评分.
主要成果:
- 观察到患者的血红蛋白,血红素,白细胞和血小板的时间依赖性下降.
- 28名患者中有6名患有急性肝衰竭 (ALF),其特征是肝酶升高,国际正常化比率和PSS.
- 患有ALF的患者血红蛋白和血小板数量进一步下降;3人死亡,1人需要进行肝移植.
结论:
- 阿曼尼塔法洛伊德 (Amanita phalloides) 中毒与血液毒性有关.
- 监测血液学参数对于管理中毒患者至关重要,特别是那些患有ALF的患者.
- 血液学变化可以作为中毒严重程度和预后的指标.
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