非洲毒素B1 损害肉骨矿化 在肉
Deependra Paneru1, Milan Kumar Sharma1, Hanyi Shi1
1Department of Poultry Science, University of Georgia, Athens, GA 30602, USA.
Toxins
|February 23, 2024
概括
brojiler 料中的 Aflatoxin B1 (AFB1) 对骨健康产生负面影响,减少矿化并破坏营养吸收. 230ppb以上的水平会损害骨质和维生素D受体功能.
科学领域:
- 动物营养 动物营养
- 毒理学 毒理学 毒理学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 非洲毒素B1 (AFB1) 是一种在玉米料中普遍存在的真菌毒素,特别是在热带地区.
- 已知AFB1暴露会导致肝损伤,氧化应激和细胞通路中断.
- 对AFB1对家禽骨健康的潜在负面影响存在担忧.
研究的目的:
- 为了研究在料中增加AFB1水平对肉肉骨矿化标记物的影响.
- 为了确定影响 brojler 骨健康的 AFB1 污染的值.
- 阐明AFB1影响骨代谢和营养吸收的机制.
主要方法:
- 一个为期19天的养试验,360只肉暴露在不同的AFB1水平 (<2,75-80,150,230-260和520-560ppb).
- 评估生长性能,骨灰含量,以及大腿骨微型计算机断层扫描 (微型CT).
- 对维生素D受体,和运输体的阴茎mRNA表达的分析.
主要成果:
- 到第19天,增长表现没有受到影响.
- 骨灰含量在AFB1水平>260ppb时显著下降.
- 微型CT检测显示,在560ppb AFB1.1.时,椎骨矿物质含量和密度降低.
- 皮层骨体积和组织体积减少了AFB1>230ppb.
- 维生素D受体,和转运体的杰表达被AFB1>75ppb下调.
结论:
- 超过230ppb的AFB1污染会通过损害骨矿化而对 brojler 骨健康产生负面影响.
- 破坏维生素D受体和/平衡有助于骨健康问题.
- AFB1对 brojlers的骨质量构成重大风险,即使在以前被认为安全生长的水平上也是如此.
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