美国多重金属暴露与总免疫球蛋白E之间的关联 大人的成年人
Xin Song1,2, Xiaowen Ding3, Piye Niu1,2
1Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, China.
Toxics
|February 23, 2024
概括
环境重金属共同暴露,特别是 (Pb) 和 (W),与免疫球蛋白E (IgE) 水平升高和过敏敏感性有关. 这项研究强调了多重金属暴露对过敏疾病标志物的影响.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 血清总免疫球蛋白E (IgE) 的升高是过敏疾病的标志.
- 环境重金属暴露与IgE水平增加和过敏有关.
- 关于多次重金属暴露对IgE的综合影响的研究有限.
研究的目的:
- 调查11种尿路重金属的同时暴露与IgE总水平之间的相关性.
- 评估重金属暴露与过敏敏感状态之间的关联.
- 使用先进的建模技术,探索联合金属暴露的影响.
主要方法:
- 从国家健康和营养检查调查 (NHANES,2005-2006) 的数据分析.
- 多重线性回归和二元逻辑回归用于单个金属-IgE相关性.
- 贝叶斯核机器回归 (BKMR) 分析混合重金属暴露效应.
主要成果:
- (Pb) 暴露与总IgE水平有显著的积极关联.
- 尿中的Pb和 (W) 与过敏敏感性发生发生有积极的相关性.
- BKMR模型证实了联合金属暴露与高IgE水平和敏感性之间的积极关联,主要由Pb和W驱动.
结论:
- 混合重金属暴露与增加的总IgE水平和过敏敏感性有关.
- 和似乎是重金属共同暴露和过敏反应之间的关键驱动因素.
- 这些发现为环境污染物和过敏性疾病之间的复杂相互作用提供了新的见解.
更多相关视频
07:10Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E sIgE
Published on: April 21, 2019
16.4K
06:34A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
10.0K
相关概念视频
Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
Antibody Structure
60.1K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.1K
Cross-reactivity
31.1K
Overview
31.1K
