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Updated: May 6, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
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在HepG2细胞中对50种复杂混合物的体外毒性查

Sunmi Kim1, Kyounghee Kang1, Haena Kim1,2

  • 1Chemical Analysis Center, Korea Institute of Chemical Technology (KRICT), Daejeon 34114, Republic of Korea.

Toxics
|February 23, 2024
PubMed
概括

这项研究产生了复杂化学混合物的实验数据,以改善混合物毒性风险评估. 大多数混合物都显示了附加效应,有一些对抗性,突出了需要先进的预测模型的需求.

关键词:
这是一种HepG2型肝炎.生物监测 生物监测复杂混合物复杂的混合物细胞毒性 细胞毒性混合物毒性预测混合物的毒性预测.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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