不同涂层相关的功能化纳米颗粒对水生生物的有毒影响
David Hernández-Moreno1, Marta Fernández-Díaz2, Isabel Rucandio2
1Department of Environment and Agronomy, National Institute of Agriculture and Food Research and Technology (INIA), Spanish National Research Council (CSIC), Carretera de A Coruña Km 7, 28040 Madrid, Spain.
Toxics
|February 23, 2024
概括
研究了不同纳米形式 (NP) 之间的毒性模式. 银纳米颗粒 (AgNP) 显示出最高的毒性,但涂层没有在物种之间建立一个明确的毒性模式,尽管物种间的敏感性有所不同.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 纳米材料 (NM) 由于其组成,尺寸,形状和表面特征的变化,具有不同的物理化学特性.
- 数量庞大的纳米形式需要分组或阅读横向策略,以进行高效的安全评估.
- 涂料通常应用于NMS以增强其性能,进一步增加纳米形式的多样性.
研究的目的:
- 在具有相同涂层的金属核心纳米粒子 (TiO2,CeO2,Ag NPs) 的纳米形式中确定一致的效果模式.
- 评估不同物种和细胞系中未涂层和涂层NP的毒性.
- 了解涂料对纳米粒子毒性和物种间敏感性的影响.
主要方法:
- 暴露 *Daphnia magna*,彩虹鱼和鱼细胞系 (PLHC-1,RTH-149) 不同度的未涂层和涂层金属核心纳米粒子 (TiO2,CeO2,Ag NP).
- 使用酸盐,聚 (乙烯基醇),十二酸和烯胺作为涂料.
- 评估水生生物和细胞系的毒性,以确定模式和敏感性.
主要成果:
- 银纳米颗粒 (AgNP) 具有最高的毒性,其次是氧化 (CeO2) NP,然后是二氧化 (TiO2) NP.
- 对于研究物种的涂层,没有明确的毒性模式.
- 观察到显著的物种间敏感性差异,其中RTH-149细胞系是最敏感的,而*Daphnia magna*显示出比鱼类更高的敏感性.
结论:
- 虽然AgNP始终是最有毒的,但纳米粒子涂层不能在物种之间产生可预测的毒性模式.
- 跨物种的敏感性有所不同,这突显了在纳米毒理学中使用多种试验生物的重要性.
- 在*Daphnia magna*中发现了涂层和金属芯之间的特定相互作用,这表明了复杂的环境行为.
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