来自梨种子的活性碳作为微提取技术的吸收阶段:激活,表征和分析性能
Alejandra Molina-Balmaceda1, Valentina Rojas-Candia1, Daniel Arismendi1
1Department of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, P.O. Box 233, Santiago, Chile.
Analytical and bioanalytical chemistry
|February 23, 2024
概括
梨种子活性炭为固态微提取提供了一个可持续的,具有成本效益的替代方案. 这种绿色化学方法的效率与商业吸附剂的效率相当,用于提取布洛芬及其代谢物.
科学领域:
- 绿色分析化学 绿色分析化学
- 材料科学 材料科学 材料科学
- 环境科学 环境科学
背景情况:
- 农业副产品是有价值的,因为它们的纤维素原产地,提供可生物降解和廉价的吸附剂相.
- 可持续的吸附剂开发对于推进绿色分析化学原理至关重要.
- 梨种子是一种丰富的农业副产品,以前没有作为吸收材料被探索过.
研究的目的:
- 研究梨种子及其活性碳作为固态微提取的可持续吸收材料的潜力.
- 为了优化梨种子活性炭 (AC) 的制备,提高提取效率.
- 为了评估梨种子AC在用于制药分析的旋转盘吸附提取 (RDSE) 的性能.
主要方法:
- 梨种子活性炭是使用化作为激活剂在600°C时制备的.
- 旋转磁盘吸附提取 (RDSE) 被用作模型技术.
- 气色谱与质谱学 (GC-MS) 结合使用气色谱进行分析.
主要成果:
- 在600°C以1:1:2浸比率 (ZnCl2) 制备的活性炭表现出更高的提取效率.
- 鉴定结果显示,与原始梨种子相比,活性炭的表面积和毛孔体积增加,这表明毛孔填充和π-π堆叠是主要的相互作用.
- 在最佳的RDSE条件下,对ibuprofen和1-hydroxy-ibuprofen的检测限值分别为0.23和0.07μg L-1和恢复率分别为81%和91%.
结论:
- 梨种子活性炭是一种可行和可持续的替代商业吸收材料,如Oasis® HLB和C18用于RDSE.
- 开发的方法为提取制药化合物提供了高灵敏度和高效率.
- 这项研究强调了利用农业废物开发环保分析工具的潜力.
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