[患有多发性硬化症的妇女怀孕和母乳养]
Laura Witt1, Sandra Thiel1, Kerstin Hellwig2
1Neurologische Klinik St. Josef Hospital, Ruhr-Universität Bochum, Gudrunstraße 56, 44791, Bochum, Deutschland.
Der Nervenarzt
|February 23, 2024
概括
患有多发性硬化症 (MS) 的妇女可以在仔细考虑疾病活动和治疗的情况下计划怀孕. 在怀孕和母乳养期间管理MS存在有效的选择,优先考虑母亲和婴儿的福祉.
科学领域:
- 神经学 神经学
- 生殖医学 生殖医学
- 免疫学 免疫学 免疫学
背景情况:
- 在生育年龄的妇女中,多发性硬化症 (MS) 诊断在生育和哺乳方面带来了独特的挑战.
- 多发性硬化本身通常不会增加怀孕并发症或不良结果的风险.
研究的目的:
- 为妇女生育年龄管理多发性硬化症提供指导,重点关注怀孕和母乳养.
- 为患有多发性硬化症的孕妇和哺乳期母亲概述最佳治疗策略.
主要方法:
- 审查当前的治疗指南和临床数据来管理MS在怀孕期间和产后.
- 在生殖的背景下,分析各种疾病修饰疗法的安全性和有效性概况.
主要成果:
- 患有多发性硬化症的妇女的怀孕需要仔细规划,以选择平衡母亲的益处和胎儿风险的治疗方法.
- 对于高度活跃的MS,抗CD20抗体,cladribine或natalizumab提供了可靠的数据.
- 一些治疗方法,包括干扰素β,glatiramer乙酸和ofatumumab,已被批准用于母乳养,其他单克隆抗体的非标签使用是可能的.
结论:
- 战略规划使得患有多发性硬化症的妇女能够安全生育和哺乳.
- 治疗决策应根据疾病活动和生殖状况进行个性化.
- 建议在有高度活跃多发性硬化症史的妇女早期开始产后治疗.
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