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甲状腺自身免疫和2型糖尿病患者的骨矿物密度之间的关联:一个横截面研究
Zhen Wang1, Jia Bai1, Jingyi Zou1
1The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, PR China.
Endocrine
|February 23, 2024
概括
甲状腺自身免疫,以甲状腺过氧化酶抗体 (TPOAb) 和甲状腺球蛋白抗体 (TGAb) 表示,与2型糖尿病 (T2DM) 患者的较低骨矿物密度 (BMD) 有关. TPOAb独立地影响糖尿病骨质疏松症.
科学领域:
- 内分泌学 在内分泌学.
- 代谢性骨疾病 代谢性骨疾病
- 免疫学 免疫学 免疫学
背景情况:
- 2型糖尿病 (T2DM) 与骨折风险增加有关.
- 甲状腺自身免疫在T2DM患者中很普遍.
- 在T2DM中甲状腺自身免疫和骨健康之间的关系需要进一步阐明.
研究的目的:
- 在T2DM患者中调查甲状腺自身免疫和骨矿物密度 (BMD) 之间的关联.
- 确定甲状腺自身免疫对糖尿病骨质疏松症发展的影响.
主要方法:
- 601名T2DM患者被分为甲状腺自身免疫阳性 (TPOAb+或TGAb+) 和阴性 (TPOAb-和TGAb-) 组.
- 骨矿物质密度 (BMD) 使用双能X射线吸收计 (DXA) 进行评估.
- 回归分析确定了 BMD 的影响因素,ROC 曲线确定了骨质疏松症查的最佳 TPOAb 切线.
主要成果:
- 甲状腺过氧化酶抗体 (TPOAb) 和甲状腺蛋白抗体 (TGAb) 与腰椎 (LS),大腿 (FN) 和手腕 (WB) 的BMD和T-分数呈负相关性.
- TGAb与25(OH) D水平有负相关性.
- TPOAb成为LS,FN和WB BMD的独立预测因子,骨质疏松症的最佳预测值为12.35.
结论:
- 甲状腺自身免疫,特别是TPOAb和TGAb的升高,与T2DM患者的骨质量降低有关.
- TPOAb是糖尿病骨质疏松症的独立风险因素.
- TPOAb在预测糖尿病骨质疏松症的发生和进展方面表现出临床实用性.
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