肥胖导致多囊性卵巢综合征中的端粒缩短
Gislaine Satyko Kogure1, Carolina Gennari Verruma1, Barbara A Santana2
1Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP), Ribeirao Preto, Brazil.
Reproductive sciences (Thousand Oaks, Calif.)
|February 23, 2024
概括
多囊卵巢综合征 (PCOS) 与白细胞端粒长度 (LTL) 的延长有关. 然而,PCOS患者的超重和肥胖会逐渐缩短LTL,这可能会影响生殖健康.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 遗传学 遗传学 是一个
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种常见的内分泌疾病,影响生育年龄的女性.
- 肥胖在PCOS中非常普遍,发生在38%至88%的受影响个体中.
- 端粒长度是细胞衰老的标志物,受遗传和环境因素的影响,包括荷尔蒙状况和体重.
研究的目的:
- 为了比较PCOS妇女的白细胞端粒长度 (LTL) 在不同的身体质量指数 (BMI) 类别 (正常,超重,肥胖) 中.
- 调查PCOS中LTL和临床/生化变量之间的关系,独立于BMI.
- 探索PCOS,BMI,雄激素和炎症标志物与端粒生物学之间的关联.
主要方法:
- 一项涉及348名妇女的横截面研究 (243名患有PCOS,105名对照).
- 评估人类测量指标,荷尔蒙特征 (,安德罗,雌激素,LH,FSH,SHBG,FAI),代谢标志物 (胰岛素,葡萄糖,HOMA-IR) 和炎症标志物 (CRP,同类蛋白).
- 使用定量聚合酶链反应 (qPCR) 来量化白细胞端粒长度 (LTL).
主要成果:
- 与非PCOS对照组相比,患有PCOS的女性体重,腰围,BMI,丸激素,LH,禁食胰岛素,FAI和HOMA-IR都较高,E2和SHBG也较低.
- 与对照组相比,PCOS亚组的LTL总体上较长,但超重和肥胖的PCOS女性的LTL明显低于正常体重的PCOS女性.
- 一般化的线性模型将BMI,androstenedione,homocysteine和CRP确定为与端粒长度相关的重要因素.
结论:
- 患有PCOS的女性通常呈现较长的LTL,可能受到过高雄性质的影响.
- 超重和肥胖有助于PCOS中逐渐缩短端粒,这可能对生殖结果产生影响.
- 安德二可能与LTL增加有关,而BMI,炎症和代谢因素在PCOS中的端粒动态中起作用.
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