神经精神和认知症状:同一枚硬币的两面?
1Department of Geriatric Psychiatry, Akershus University Hospital, Lørenskog, Norway.
Journal of Alzheimer's disease : JAD
|February 23, 2024
概括
神经精神症状 (NPS) 是早期阿尔茨海默病 (AD) 痴呆症的关键标志物. 了解它们与认知衰退和大脑变化的联系,可以改善早期发现AD痴呆症.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 神经精神症状 (NPS) 越来越多地被认为是阿尔茨海默病 (AD) 痴呆症发病初期的临床标志物.
- NPS可能与认知障碍相互作用,可能会加剧阿尔茨海默病的下降.
- 在AD早期的NPS背后的机制,包括它们与认知症状和结构性大脑变化的关系,仍然不太了解.
研究的目的:
- 调查NPS作为早期AD痴呆症潜在临床标志物的作用.
- 探索NPS,认知衰退和阿尔茨海默病中的结构性大脑变化之间的关系.
- 确定将NPS维度纳入AD痴呆症概念是否可以改善风险检测.
主要方法:
- 关于阿尔茨海默病神经精神病症状的当前文献的综述.
- 分析NPS和认知障碍之间的关联.
- 检查将NPS与大脑缩和其他大脑结构变化联系在一起的证据.
主要成果:
- 即使在轻度认知障碍中,NPS也很常见,这表明早期参与AD过程.
- 有证据表明NPS和大脑缩之间存在关联,暗示与认知症状共享的生物途径.
- NPS可能会强化认知衰退,反之亦然,表明复杂的相互作用.
结论:
- 在了解阿尔茨海默氏症进展方面,NPS代表着一个重要的维度.
- 对阿尔茨海默病中NPS机制的进一步研究对于早期诊断和干预至关重要.
- 在AD痴呆症概念中增强NPS维度可能会改善对有风险的个体的识别.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
Disorders of the Nervous Tissue
1.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.3K
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
114
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
114
Language and Cognition
346
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
346
Positive Symptoms Schizophrenia: Hallucinations and Delusions
56
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
Hallucinations
Hallucinations in...
56
Psychosis: Goals of Pharmacotherapy
130
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
130


