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在重症COVID-19患者的认知和大脑连接轨迹

Daniela Ramos-Usuga^1,2, Antonio Jimenez-Marin^1,2, Alberto Cabrera-Zubizarreta³

¹Biobizkaia Health Research Institute, Barakaldo, Spain.

NeuroRehabilitation

|February 23, 2024

概括

患有多器官衰竭 (MOF) 的COVID-19幸存者显示大脑连接性降低,影响注意力和处理速度. 这些神经系统缺陷长期存在,突显了针对性干预的必要性.

科学领域:

神经科学是一个神经科学.
关键护理医学关键护理医学
传染性疾病传染性疾病

背景情况:

多器官衰竭 (MOF) 是COVID-19患者进入重症监护室 (ICU) 的重要原因之一.
与COVID-19相关的MOF可以导致短期和长期的神经系统缺陷.

研究的目的:

为了比较COVID-19导致的MOF与其他原因的个体的认知功能和大脑功能连接.
根据健康对照对这些功能进行评估,在离院6-12个月后.

主要方法:

对36名参与者进行了神经心理和神经成像评估 (每组12名:COVID-19 MOF,其他MOF,健康对照).
分析了休息状态功能连接,将COVID-19患者与健康对照进行比较,同时考虑MOF效应.
研究了大脑连接和认知表现之间的关系.

主要成果:

与健康对照组相比,COVID-19组在默认模式网络和 Salience 网络之间功能连接性下降.
这种低连接性与注意力和信息处理速度测试的表现较差相关.
这些发现在释放后的6个月和12个月都是一致的.

结论:

与COVID-19相关的MOF导致大脑功能连接的持续变化.
这些神经变化与认知障碍有关,特别是在注意力和处理速度方面.
了解这些长期的神经效应对于开发改善患者生活质量的干预措施至关重要.

关键词:

在 COVID-19 疫情中,大脑大脑大脑的大脑大脑认知认知认知重症监护室的重症监护室是重症监护室的重症监护室.神经成像是一种神经成像.神经心理学神经心理学

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