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时间无限的多分子ADP-ribosyl化限制了DNA复制压力,并促进了停滞的叉子保护

Julie Rageul1, Natalie Lo1, Amy L Phi1

  • 1Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

Cell reports
|February 23, 2024
PubMed
概括

聚ADP-ribosyl化 (PARylation) 向无时间 (TIM) 降解,这对DNA复制叉稳定性至关重要. 抑制多基基聚合酶 (PARP) 干扰了这一过程,导致复制应激和分叉不稳定.

关键词:
这就是BRCA1/2的原因.科普:分子生物学 分子生物学DNA复制的压力是DNA复制的压力.PARP1 的第一部分这是一个很好的机会. PTUbLLL无时无刻的时间.通过多ADP-ribosyl化.复制子反转转换 复制子一些重复的重复.乌比奎丁-蛋白酶体的存在

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