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治疗抗体对IL-6信号抑制的结构性见解

Mingxing Wang1, Long Chen1, Jin He1

  • 1MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, Anhui, China.

Cell reports
|February 23, 2024
PubMed
概括

抗体药物托西利祖马布和沙利祖马布通过与IL-6R结合来阻断介质素-6 (IL-6) 信号传递. 结构分析揭示了它们的结合机制,有助于未来对IL-6相关疾病的抗体开发.

关键词:
CP: 免疫学 免疫学抗体是一种抗体.低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.细胞因子风暴是什么意思介质蛋白-6 介质蛋白-6 是一种类风湿性关节炎 类风湿性关节炎

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