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亚致命的热应激促进甲状腺癌细胞的迁移和入侵
Chi-Yu Kuo1,2, Chung-Hsin Tsai1,2, Jun Kui Wu3
1Department of Surgery, MacKay Memorial Hospital, Taipei, Taiwan.
PloS one
|February 23, 2024
概括
亚致热处理,模仿不完全的甲状腺癌切除,意外增强了癌细胞的生长,迁移和入侵. 这一发现凸显了甲状腺癌热疗法不足的潜在风险.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
背景情况:
- 射频除是治疗良性甲状腺结节的公认方法.
- 新出现的证据表明,热除有可能用于低风险的甲状腺癌管理.
- 在临床环境中不完整的热除可能会给甲状腺癌的根除带来风险.
研究的目的:
- 为了研究亚致命热应激对差异化甲状腺癌细胞的影响.
- 在体外模仿不足的热除场景.
- 评估短暂热处理对癌细胞行为的影响.
主要方法:
- 差异化甲状腺癌细胞系 (B-CPAP,TPC-1,FTC-133) 在不同温度下进行热处理,持续10分钟.
- 评估了对细胞生长,克隆原性,伤口愈合 (迁移) 和Transwell入侵试验的影响.
- 分析了表皮层-介质细胞过渡标记物的表达.
主要成果:
- 在45°C或更高的温度下进行热处理会减少细胞生长;37-42°C的温度不会影响活力.
- 在40°C的短暂热量显著增加了克隆性 (16-39%),迁移 (1.75-2.56倍) 和入侵 (115-126%).
- 在40°C的热处理后,观察到表皮层-介质细胞过渡标记物 (ZEB1,N-cadherin,MMP2) 的升调.
结论:
- 致命的热应激可以矛盾地增强甲状腺癌细胞的攻击性.
- 即使在非致命的温度下,暂时的热处理也可能促进克隆性,迁移和入侵.
- 这些发现表明,在治疗甲状腺癌时,不完全的热除应谨慎使用.
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