使用INR识别烧伤患者的凝血病
Kendall Wermine1, Juquan Song2, Sunny Gotewal1
1School of Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.
PloS one
|February 23, 2024
概括
烧伤引起的凝血病,一个血液凝结问题,随着烧伤大小 (总烧伤表面积) 的增加,显著增加. 这种疾病与较高的死亡率有关,在老年患者和患有高血压等心脏病患者中更为普遍.
科学领域:
- 创伤外科手术是什么
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
背景情况:
- 关于烧伤引起的凝血病的临床意义存在相互矛盾的研究.
- 这项研究认为,烧伤诱导的凝血病与烧伤严重程度直接相关.
研究的目的:
- 在烧伤患者中描述凝血病的概况.
- 通过国际规范比率 (INR) 测量,确定燃烧总表面积 (%TBSA) 和凝血病的百分比之间的关系.
主要方法:
- 利用TrinetX数据库识别INR值的烧伤患者.
- 不包括有输血病史,慢性肝衰竭或服用抗凝药的患者.
- 烧伤引起的凝血病被定义为INR≥1.5的INR,在研究人群中属于INR值的第3四分位数之外.
主要成果:
- 烧伤诱导的凝血病显著增加了TBSA%的烧伤,特别是在≥20%的TBSA (p < .05).
- 与没有 (46 ± 21.8 年; p < .0001) 相比,烧伤诱导凝血病患者的年龄较大 (59 ± 21.5 年).
- 匹配分析显示,燃烧引起的凝血病患者的28天死亡风险较高 (20.9%的差异,或4.45).
- 高血压是一个显著的相关疾病 (53%的患者患有凝血病;p < .0001).
结论:
- 烧伤引起的凝血病与%TBSA烧伤直接相关.
- 这些发现清楚地表明了%TBSA与燃烧引起的凝血病之间的联系,为预后和治疗策略提供了宝贵的见解.
- 烧伤患者的凝血病与增加的死亡率和特定的并发症,如高血压有关.
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