格利皮齐德固体剂型的配方和特征 具有增强溶解性的固体剂型
Badriyah Shadid Alotaibi1, Muhammad Ahsan Khan2, Kaleem Ullah3
1Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
PloS one
|February 23, 2024
概括
这项研究使用聚乙烯 (PVP) 和聚乙烯糖醇 (PEG) 的固体分散物增强了glipizide的溶解性. 与PEG相比,基于PVP的配方显示出更高的药物释放和溶解度,导致最佳的即时释放片.
科学领域:
- 制药科学 制药科学
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 格利皮齐德是一种水溶性较差的药物,被归类为BCSII类.
- 提高这些药物的可溶性和溶解率对于改善生物可用性至关重要.
- 固体分散技术为克服可溶性挑战提供了一个有前途的方法.
研究的目的:
- 为了提高glipizide的可溶性和溶解率.
- 使用聚乙烯 (PVP) 和聚乙烯糖醇 (PEG) 制备和描述glipizide固体分散物.
- 评估不同药物与聚合物比率和聚合物类型对glipizide制药性质的影响.
主要方法:
- 使用溶剂蒸发方法制备了glipizide固体分散物.
- 使用了各种药物与聚合物的比率 (1:1, 1:2, 1:3, 1:4) 和聚合物 (PVP K30,PVP K90,PEG 6000).
- 在pH 6.8和37°C下使用USP II型装置进行了体外溶解研究.
- 固态特征包括FTIR,XRD和DSC来评估药物聚合物相互作用.
主要成果:
- 与物理混合物和纯药物相比,固体分散显著提高了glipizide的可溶性和溶解率.
- 有较高聚合物度的配方显示出更好的溶解性.
- 基于聚乙烯 (PVP) 的固体分散物表现出比聚乙烯甘醇 (PEG) 更有利的药物释放特征.
- 鉴定性研究证实了glipizide和所使用的聚合物之间的兼容性.
结论:
- 固体分散技术有效地提高了水溶性较差的glipizide的可溶性和溶解性.
- 聚乙烯罗利 (PVP) 是一种适合用于开发具有改善释放特性的glipizide固体分散物的载体.
- 优化的固体分散配方已成功转化为符合药典标准的即时释放片.
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