探索早期结肠直肠癌的人口差异和结果
Beas Siromoni1, Adrienne Groman2, Kanak Parmar3
1University of South Dakota, Vermillion, SD.
JCO oncology practice
|February 23, 2024
概括
农村地区的早期结直肠癌 (EOCRC) 患者面临更高的发病率和死亡率. 与大都市地区患者相比,这些患者的生存结果也更差,这突出了显著的地理差异.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 早期结直肠癌 (EOCRC) 的发病率在全球范围内正在上升.
- EOCRC通常与环境因素有关,而不是遗传因素.
- 怀疑EOCRC的社会人口差异,但需要进行调查.
研究的目的:
- 研究早期结直肠癌的地理差异.
- 根据居住地点 (大都市与农村) 分析生存结果.
主要方法:
- 对SEER数据库 (1976-2016) 的回顾性分析.
- 包括73,378名被诊断患有EOCRC的患者.
- 对社会人口统计因素和生存率 (OS,DSS) 的单变量和多变量分析.
主要成果:
- 农村地区 (RA) 的EOCRC发病率和死亡率高于大都市地区 (MA).
- 关节炎患者的整体存活率 (OS) 和疾病特异性存活率 (DSS) 明显低于MA患者.
- 非西班牙裔黑人种族,无保险身份和未婚身份与较差的生存结果有关.
结论:
- 生活在农村地区与EOCRC患者的结果更差有关.
- 了解和解决社会经济差异对于改善EOCRC患者的治疗结果至关重要.
- 未来的研究应该专注于推动这些差异的机制,以告知干预措施.
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