血液尿素和COVID-19患者的临床预后:一项回顾性研究
Jiangtao Yin1, Yuchao Wang2, Hongyan Jiang3
1Department of Critical Care Medicine, Digestive Disease Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, People's Republic of China.
Medicine
|February 23, 2024
概括
血尿酸 (BUN) 水平升高与COVID-19患者28天死亡率的增加有关. 较高的BUN表明死亡风险更高,这表明BUN是COVID-19的预后标志物.
科学领域:
- 传染性疾病 传染性疾病
- 临床医学 临床医学
- 生物化学 生物化学
背景情况:
- COVID-19带来了重大的临床挑战,需要可靠的预后标志物.
- 了解影响患者结果的因素对于有效管理至关重要.
研究的目的:
- 为了研究血液尿素 (BUN) 与COVID-19患者28天临床预后之间的关联.
- 评估BUN作为COVID-19死亡率的潜在预测因素.
主要方法:
- 一项多中心的回顾性研究,涉及141名成年COVID-19患者.
- 根据28天的结果将患者分为生存和死亡组.
- 使用双变物流回归和ROC曲线分析来评估BUN的预测值.
主要成果:
- 与幸存者相比,在28天内死亡的患者表现出明显更高的BUN水平.
- BUN被确定为28天死亡率的一个显著风险因素 (AUC = 0.796).
- 7.37 mmol/L的BUN截止值显示了84.62%的灵敏度和70.31%的特异性来预测死亡率.
结论:
- 升高的BUN水平与COVID-19患者28天死亡率的增加有关.
- 超BUN (≥7.37 mmol/L) 作为COVID-19中预后不佳的有价值预测指标.
- BUN监测可能有助于COVID-19患者的风险分层和临床决策.
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