2型糖尿病患者中维生素D缺乏的决定因素:一项回顾性研究
Sami Hamdan Alzahrani1,2, Mukhtiar Baig3, Khaled A Yaghmour1
1Department of Family Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
维生素D缺乏 (VDD) 在2型糖尿病 (T2DM) 患者中非常普遍,其中83.7%受影响. 低维生素D水平与高HbA1c和T2DM个体的肥胖有关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 营养科学 营养科学
背景情况:
- 维生素D缺乏 (VDD) 越来越多地与2型糖尿病 (T2DM) 相关.
- 在T2DM患者中VDD的确切关系和决定因素需要进一步澄清.
- 了解这种联系对于全面的糖尿病管理至关重要.
研究的目的:
- 估计T2DM患者中VDD的发生率.
- 确定T2DM个体中糖尿病和VDD决定因素之间的关系.
- 为临床实践提供有关糖尿病管理中维生素D状态的信息.
主要方法:
- 在阿卜杜拉齐兹国王大学医院进行了一项回顾性横截面研究.
- 招募了864名受试者,分析了维生素D水平,HbA1c和其他参数.
- 根据HbA1c水平对受试者进行分类:正常 (<5.7%),受损 (5.7-6.49%) 和糖尿病 (>6.5%).
主要成果:
- VDD的患病率很高,影响了83.7% (723/864) 的受试者.
- 与非糖尿病患者相比,糖尿病患者的维生素D水平明显较低 (29.1 ± 12.0 与 44.0 ± 28.3 相比,P < .001).
- VDD与年龄较大 (>50岁),超重/肥胖以及HbA1c升高,禁食血葡萄糖,和总胆固醇有关.
结论:
- 在T2DM患者中存在高发病率的VDD,在这个群体中观察到显著较低的维生素D水平.
- 在T2DM中VDD的关键决定因素包括年龄,超重/肥胖,HbA1c和禁食血葡萄糖.
- 解决维生素D状况对于管理和潜在预防T2DM至关重要,特别是在风险人群中.
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