评估COVID-19疫苗的短期不良事件:一个观察性研究
Fatemeh Fathi1, Ali Ameri1, Omid Safa2
1Student Research Committee, Faculty of Pharmacy, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Medicine
|February 23, 2024
概括
来自Sputnik V,AstraZeneca和Sinopharm的COVID-19疫苗被评估为短期不良事件 (AE). 阿斯特拉泽内卡的局部和全身AE比Sinopharm更多,疲劳和注射部位疼痛是最常见的. 所有的疫苗都是安全的和可以容忍的.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- COVID-19疫苗对于大流行管理至关重要.
- 人们对接种疫苗后可能发生的不良事件 (AE) 存在担忧.
- 了解短期副作用对于疫苗接受和安全监测至关重要.
研究的目的:
- 为了评估和比较Sputnik V,AstraZeneca和Sinopharm COVID-19疫苗的短期不良事件.
- 确定局部和全身并发症的患病率和类型.
- 评估这些疫苗的安全性和耐受性.
主要方法:
- 一项涉及321名接种疫苗的个体的横截面研究.
- 通过在线调查问卷收集的数据.
- 评估包括人口统计,疫苗接种细节和报告的不良事件 (局部,全身,过敏).
主要成果:
- 与Sputnik V和Sinopharm相比,AstraZeneca疫苗与局部 (疼痛,胀) 和全身 (发烧,疲劳,昏迷) 副作用的患病率较高有关.
- 疲劳和昏迷是最常见的系统性副作用;淋巴腺病是最不常见的.
- 西诺法姆公司显示,AE的患病率较低. 与AstraZeneca一起报告了像面部这样的罕见副作用.
- 接种第二剂疫苗后,系统性并发症的严重程度增加.
结论:
- 这三种COVID-19疫苗 (Sputnik V,AstraZeneca,Sinopharm) 都被发现是安全的和可以容忍的.
- 常见的副作用包括注射部位疼痛和系统性影响,如疲劳.
- 观察到的副作用通常是短期的,表明早期免疫反应.
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