高葡萄糖摄入量加剧了实验性自身免疫性前列腺炎通过线粒体反应性氧物种依赖的TGF-β激活介导的Th17分化
Di Niu1, Shao-Yu Yue1, Xu Wang1
1Department of Urology, the First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, PR China; Institute of Urology, Anhui Medical University, Hefei, Anhui, PR China; Anhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Anhui Medical University, Hefei, Anhui, PR China.
International immunopharmacology
|February 23, 2024
概括
高葡萄糖摄入量通过促进Th17细胞反应,使慢性前列腺炎/慢性骨盆疼痛综合征 (CP/CPPS) 恶化. 这种恶化与线粒体的活性氧物种和TGF-β激活有关.
科学领域:
- 免疫学 免疫学 免疫学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢性疾病 代谢性疾病
背景情况:
- 慢性前列腺炎/慢性盆腔疼痛综合征 (CP/CPPS) 是一种普遍的炎症性疾病.
- 高葡萄糖摄入量被怀疑是自身免疫性疾病发展的一个因素.
- 高葡萄糖对CP/CPPS的具体影响及其机制尚不清楚.
研究的目的:
- 研究高葡萄糖摄入量如何影响实验性自身免疫性前列腺炎 (EAP),CP/CPPS的动物模型.
- 阐明连接高葡萄糖摄入量与EAP病变的潜在分子机制.
主要方法:
- 在EAP诱导过程中,NOD小鼠被给予高葡萄糖水.
- 评估了EAP的严重程度和T助手17 (Th17) 细胞的反应.
- 经过测试的干预措施包括IL-17A中和,TGF-β抑制和抗氧化剂 (NAC,MitoQ).
主要成果:
- 高葡萄糖摄入量显著恶化了EAP的严重程度,并增加了Th17细胞的产生.
- IL-17A 中和改善了高葡萄糖诱导的EAP.
- 在体外,高葡萄糖通过线粒体ROS依赖的TGF-β激活促进了Th17的分化.
- 在体内和体外,TGF-β阻断,NAC和MitoQ抑制了Th17生成并减轻了EAP.
结论:
- 高葡萄糖摄入量通过线粒体ROS依赖的TGF-β激活促进Th17细胞分化,加剧EAP.
- 这些发现强调了环境因素 (如饮食) 在CP/CPPS中的作用.
- 这项研究为潜在的治疗策略提供了对分子途径的洞察.
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