CDH1基因突变,一个具有挑战性的外科主题:病例报告和文献综述
Hani Maalouf1, Toufic Saber1, Souad Ghattas1
1Department of General Surgery, University of Balamand, Beirut, Lebanon.
International journal of surgery case reports
|February 23, 2024
概括
遗传性扩散性胃癌 (HDGC) 与CDH1基因有关. 建议对具有CDH1基因的个体进行预防性全胃切除,以预防胃癌,并密切监测乳腺癌.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 手术瘤学手术瘤学
背景情况:
- 胃癌在全球排名前五,遗传性扩散性胃癌 (HDGC) 是一种罕见的亚型.
- HDGC与CDH1瘤抑制基因的生殖基因突变密切相关,表现出高透率.
- CDH1基因的功能丧失显著提高了终身癌症风险.
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