根据癌症类型,静脉血栓栓塞的风险:一个网络的元分析
Marissa B Betts1, Xuejun Liu2,3, Daniela R Junqueira1
1Evidera, Waltham, Massachusetts.
Seminars in thrombosis and hemostasis
|February 23, 2024
概括
癌症患者面临更高的静脉血栓栓塞 (VTE) 风险. 胰腺癌,脑癌和卵巢癌的风险较高,由病期,化疗和手术影响.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 患有癌症的患者表现出静脉血栓塞栓症 (VTE) 的风险较高.
- 准确比较瘤特异性静脉瘤风险是具有挑战性的,因为混因素,如手术,疾病阶段,和化疗.
- 网络元分析 (NMA) 提供了一种可靠的方法来估计不同癌症类型的VTE率,同时考虑基线风险.
研究的目的:
- 根据癌症类型估计静脉瘤风险.
- 确定影响癌症患者静脉瘤风险的因素.
主要方法:
- 在Embase,MEDLINE和Cochrane图书馆 (2005-2022) 的系统文献搜索.
- 包括临床试验和观察性研究,评估至少两种不同类型的癌症中初级癌症相关的VTE.
- 随机效应贝叶斯网络元分析 (NMA) 估计相对VTE率,以肺癌VTE发病率为绝对率.
主要成果:
- 包括30项研究,包括3,948,752名患者和18种癌症类型.
- 诊断后一年内整体VTE发病率为3.1%,癌症特异性发病率从0.7%到7.4%不等.
- 胰腺癌,大脑癌和卵巢癌显示,VTE风险高于平均水平. 风险排名受疾病阶段,化疗和手术的影响.
结论:
- 该研究使用NMA成功估计了癌症特异性VTE风险,提供了一个比较框架.
- 发现某些癌症的VTE风险排名是动态的,受疾病阶段,化疗和手术干预的影响.
- 这些发现有助于完善VTE风险分层和癌症患者的管理策略.
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