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个性化医疗的衰老特征,生物标志物和时钟: (重新) 定位聚光灯

M Cristina Polidori¹

¹Aging Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Herderstraße 52, 50931, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress- Responses in Aging- Associated Diseases (CECAD), University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Free radical biology & medicine

|February 23, 2024

概括

老龄化科学推进了长寿,但缺乏个性化健康策略. 未来的努力需要生物老年学家和老年医生之间的跨学科对话,以将衰老研究转化为实际的健康措施.

科学领域:

老年学和老年医学是老年学和老年医学.
关于衰老的翻译研究

背景情况:

老龄化日益普遍和复杂,对科学和医学界构成了挑战.
在基础研究,临床指南和个性化策略之间存在差距,以改善老年人的生活质量.

研究的目的:

突出跨学科对话的必要性,以弥合衰老的研究和临床实践.
强调将衰老机制转化为可行的健康干预措施的重要性.

主要方法:

审查老龄化科学和长寿研究当前的进展.
对翻译研究和临床应用现有差距的分析.

主要成果:

衰老科学已经揭示了衰老机制和延长寿命的技术.
目前的重点是生存,对个性化策略增强功能和福祉的证据较少.

结论:

生物学家和老年医生之间的更密切的对话至关重要.
将衰老表型,时钟和生物标志物转化为临床实践对于改善健康寿命和生活质量至关重要.

关键词:

衰老的衰老衰老的衰老生物标志物生物标志物脆弱性脆弱性脆弱性标志性的标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标志标

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