提高药物术语的互操作性:将当地标准化注入国际视角
Jean Noël Nikiema1, James Liang2, Man Qing Liang3
1Department of Management, Evaluation and Health Policy, School of Public Health, Université de Montréal, Canada; Centre de recherche en santé publique, Université de Montréal et CIUSSS du Centre-Sud-de-l'Île-de-Montréal, Canada; Laboratoire Transformation Numérique en Santé (LabTNS), Canada.
Journal of biomedical informatics
|February 23, 2024
概括
加拿大药物本体学 (OCRx) 将当地药物数据与国际标准相结合. 未来的工作旨在加强对现实应用的分类和剂量转换.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物信息学是一种生物信息学.
- 医疗信息学 医疗信息学
背景情况:
- 将当地药物信息与国际标准相结合,对于药物数据管理至关重要.
- 现有的药物本体学可能无法完全解决加拿大特点或国际要求,如IDMP.
研究的目的:
- 描述加拿大药物本体学 (OCRx) 的发展.
- 确保OCRx与国际标准 (IDMP) 和加拿大当地药物信息需求保持一致.
- 详细说明OCRx.的结构,对齐和访问服务.
主要方法:
- 开发了OCRx以满足药品识别 (IDMP) 的要求.
- 构建了本体论,并实施了更新策略.
- 与SNOMED CT,RxNorm和CIS代码对齐的OCRx.
- 创建了查找服务,包括PaperRx,SPARQL端点,OWL下载器和RESTful API.
主要成果:
- OCRx包括两个版本:一个完整版本 (162,400类) 和一个最新版本 (36,909类).
- 通过参考系统进行映射覆盖:RxNorm (37%),SNOMED CT (22%),CIS-Code (61%).
- 临床药物映射主要使用后协调表达式 (RxNorm 56%,SNOMED CT 80%,CIS-Code 35%).
结论:
- OCRx代表了加拿大药物数据与国际标准整合的重要一步.
- 未来的工作重点是改进分类,剂量转换和开发基于本体学的注释器,以实现现实数据集成.
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