基于运动的心脏瘤康复,用于预防乳腺癌化疗期间的心脏毒性:ONCORE随机对照试验
Estíbaliz Díaz-Balboa1, Carlos Peña-Gil2, Beatriz Rodríguez-Romero3
1University of A Coruña, Department of Physiotherapy, Medicine and Biomedical Sciences, Campus de Oza, A Coruña 15071, Spain; Cardiology Department, University Clinical Hospital of Santiago de Compostela (SERGAS); Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 15706 Santiago de Compostela, A Coruña, Spain; Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, A Coruña, Spain.
Progress in cardiovascular diseases
|February 23, 2024
概括
涉及运动的心脏瘤康复 (CORe) 计划在预防乳腺癌患者的癌症治疗相关心脏功能障碍 (CTRCD) 中表现有前途. 在接受心脏毒性治疗的肥胖患者中,CORE也可能有助于降低BMI.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 心脏康复心脏康复
- 乳腺癌治疗并发症 乳腺癌治疗并发症
背景情况:
- 乳腺癌 (BC) 治疗方法,如 antracyclines 和 anti-HER2 疗法,可以导致心血管并发症,包括与癌症治疗有关的心脏功能障碍 (CTRCD).
- 为了减轻这些风险,正在探索包括运动在内的心脏瘤康复 (CORe) 计划,但它们在预防CTRCD方面的有效性仍然不确定.
研究的目的:
- 评估基于运动的CORE计划在接受心脏毒性治疗的早期乳腺癌患者中预防CTRCD的有效性.
- 评估二次结果,包括心脏生物标志物,身体表现,心理测量,生活方式因素,安全性,坚持和患者满意度.
主要方法:
- 一项随机对照试验,涉及122名接受心脏毒剂的早期BC妇女.
- 参与者被随机分配到一个CORe计划 (n=60) 或常规护理与运动建议 (n=62).
- 在基线和治疗后进行了全面的评估,平均干预时间为5.8个月.
主要成果:
- 在这两组中都没有观察到CTRCD的情况.
- 与常规护理组相比,在CORe组中,左心室喷射分数 (LVEF) 的下降显著减弱 (p=0.006).
- CORe干预导致体重指数 (BMI) 显著降低,特别是在肥胖患者中 (p=0.037),没有报告任何不良事件.
结论:
- 基于炼的CORE计划在减轻接受心脏毒性治疗的乳腺癌患者的LVEF下降方面似乎是安全有效的.
- CORe也可能有助于减轻肥胖患者的BMI,这表明它在管理与治疗相关的副作用方面起着有益的作用.
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