与阿伦德罗纳酸相比,用德诺苏马布治疗的患者的癌症风险:基于人口的队列研究
Sam Kafai Yahyavi1, Rune Holt1, Nadia Krarup Knudsen1
1Division of Translational Endocrinology, Department of Endocrinology and Internal Medicine, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark; Group of Skeletal, Mineral, and Gonadal Endocrinology, Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Denmark.
Bone
|February 23, 2024
概括
与阿伦德罗纳酸相比,在三年内,德诺苏马布治疗没有增加生殖癌症的风险. 这项研究为使用德诺苏马布治疗骨质疏松症和癌症的患者提供了保证.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 像德诺苏马布这样的抗吸收药物广泛用于骨质疏松症和癌症.
- 以前的研究表明,登索苏马布与卵巢癌之间存在潜在的联系,它可能刺激生殖细胞的增殖.
- 这项研究探讨了使用德诺苏马布和生殖癌症风险与阿伦德罗纳特之间的关联.
研究的目的:
- 为了确定使用德诺苏马布是否与生殖系统癌症的风险增加有关.
- 为了比较denosumab用户与alendronate用户的生殖癌症风险.
主要方法:
- 一项使用2010-2017年丹麦全国性注册表的队列研究设计.
- 确定了年龄≥50岁的患者,在至少六个月的阿伦德罗纳特治疗后开始服用德诺苏马布.
- 匹配了denosumab队列1:2与单独使用alendronate的患者,使用纵向向最大概率估计 (L-TMLE) 来评估癌症风险.
主要成果:
- 这项研究包括6054名德诺苏马布使用者和12108名阿伦德罗纳特使用者.
- 三年后,使用德诺苏马布的绝对生殖癌症风险为1.05%,与使用阿伦德罗纳特 (0.03%) 没有显著差异.
- 与阿伦德罗纳特或一般人群相比,在使用德诺苏马布时没有观察到非生殖性癌症的风险增加.
结论:
- 在三年后的随访中,在denosumab和alendronate治疗之间没有发现癌症风险差异.
- 这些发现表明,在短期内,德诺苏马布与生殖系统癌症的风险增加无关.
相关概念视频
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:21Cancer Survival Analysis
346
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
346
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:12Hazard Ratio
122
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
122
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
126
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
126