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乳杆菌衍生的抗炎性外聚糖的特异性差异和机制

Jie Zhang¹, Huiqin Zhang¹, Yue Xiao²

¹State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.

International journal of biological macromolecules

|February 23, 2024

概括

乳杆菌外聚糖 (EPSs) 显示抗炎作用,但在物种之间有所不同. 某些EPS,特别是富含果糖的EPS,通过调节细胞因子水平和巨细胞反应,在体内表现出强大的抗炎活性.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

乳杆菌衍生的外聚糖 (EPS) 以其抗炎性质而闻名.
乳杆菌EPSs抗炎功效的跨种类差异在很大程度上仍未被探索.

研究的目的:

为了研究乳杆菌衍生的EPSs的抗炎作用的跨种类变异.
阐明这些EPSs在体外和体内不同的抗炎活性背后的机制.

主要方法:

在体外细胞实验中评估抗炎疗效.
在体内小鼠的大肠炎模型中,用来自五种乳杆菌种的EPSs治疗.
对细胞因子 (TNF-α,IL-1β,IL-6,TNF-γ,IL-17,IL-10) 和巨细胞两极分化的分析.
结构-活动关系分析,重点关注EPS成分,特别是果糖含量.

主要成果:

所有测试的Lactobacillus EPS在体外表现出一些抗炎作用.
在肠道屏障修复方面没有观察到显著的跨物种差异.
在体内,Ligilactobacillus salivarius和Lactiplantibacillus plantarum EPSs表现出优异的炎症性细胞因子减少和增加IL-10.
抗炎活性的跨种类变异与对巨细胞透和两极分化的差异性影响有关.
乳酸菌EPS中的高果糖含量与体内增强的抗炎活性相关.

结论:

乳杆菌衍生的EPS在它们的抗炎性潜力中表现出跨种类的变异性.
乳杆菌EPSs的作用机制在体外和体内环境之间有所不同.
果糖含量是影响Lactobacillus EPSs在体内抗炎功效的关键结构特征.

关键词:

具有抗炎能力的抗炎能力.跨种类差异的不同.乳杆菌衍生出的外聚糖类.

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