相关实验视频

Updated: Jul 2, 2025

Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae

Chitosan/Interfering RNA Nanoparticle Mediated Gene Silencing in Disease Vector Mosquito Larvae

Published on: March 25, 2015

非编码RNA疗法的基托纳米载体:一篇综述

S Karthik¹, Sahithya Mohan¹, Induja Magesh¹

¹Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India.

International journal of biological macromolecules

|February 23, 2024

概括

基托桑纳米载体为提供非编码RNA (ncRNA) 疗法提供了一个有希望的解决方案. 这些纳米载体保护ncRNAs,并使其能够针对性地用于治疗各种疾病.

科学领域:

生物材料科学生物材料科学
在RNA治疗方面,RNA疗法.
纳米技术纳米技术

背景情况:

非编码RNA (ncRNA) 疗法显示出治疗感染,癌症,神经疾病和骨异常的潜力.
将ncRNA传递到特定的细胞点仍然是一个重大挑战,限制了它们的治疗疗效.
奇托 (CS) 是一种生物相容的阴性聚合物,可以与负电荷的ncRNAs形成稳定的复合物,为纳米载体发展提供了一个可行的选择.

研究的目的:

审查基于基托 (CS) 的纳米载体用于非编码RNA (ncRNA) 治疗的最新进展.
讨论CS纳米载体在治疗各种疾病中的合成,设计和应用.
确定与基于CS的纳米载体相关的挑战和局限性,并提出改进策略.

主要方法:

关于酸盐纳米载体合成和设计的最新进展的文献综述.
对CS纳米载体在不同疾病的ncRNA疗法中的应用进行分析.
讨论基于CS的ncRNA传递系统的挑战和未来战略.

主要成果:

素纳米载体有效地保护ncRNAs免受降解.
表面修改和受控释放配置文件使得ncRNAs的向传递成为可能.
基于CS的纳米载体在各种治疗应用中显示出潜力.

结论:

酸盐纳米载体代表了推进ncRNA治疗的有希望的平台.
进一步研究克服目前的局限性可以提高基于CS的ncRNA传递系统的临床翻译.
优化的CS纳米载体可以提高基于ncRNA的治疗方法对许多疾病的疗效和特异性.

关键词:

基托桑是一种酸盐.药物输送是药物输送的过程.纳米载体的使用方法没有编码的RNAs.治疗方法治疗方法组织工程是组织工程.

更多相关视频

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

相关概念视频

siRNA - Small Interfering RNAs

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

Experimental RNAi

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...