相关实验视频

Updated: May 5, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Published on: July 16, 2018

肠道微生物代谢物三甲基胺N-氧化物诱导大动脉剖析

Shan Huang¹, Shijuan Gao¹, Yihui Shao¹

¹Collaborative Innovation Centre for Cardiovascular Disorders, the Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China; Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

Journal of molecular and cellular cardiology

|February 23, 2024

概括

三甲基胺N氧化物 (TMAO) 是肠道微生物代谢物,通过促进内皮功能障碍和炎症,显著提高了大动脉剖析 (AD) 的风险和严重程度. 减少TMAO可能为这种灾难性的血管疾病提供新的治疗策略.

科学领域:

心血管研究研究心血管研究
肠道微生物组研究研究
血管生物学血管生物学

背景情况:

大动脉解剖 (AD) 是一种危及生命的血管紧急情况,死亡率高.
肠道微生物代谢物三甲基胺N-氧化物 (TMAO) 与心血管疾病有关,但其在AD中的作用尚不清楚.

研究的目的:

调查TMAO对大动脉解剖的发展和进展的影响.
阐明TMAO影响AD病变的潜在机制.

主要方法:

对阿兹海默症患者和健康对照者的血TMAO度和肠道微生物群的分析.
动物模型的AD (angiotensinII或β-aminopropionitrile诱导) 与TMAO补充或耗尽.
甲状腺内皮细胞的RNA测序和体外测试以评估内皮功能和炎症信号.

主要成果:

与健康受试者相比,AD患者的血TMAO水平显著提高,肠道微生物组成发生变化.
在动物模型中,TMAO补充会加剧AD的发展,而TMAO耗尽会减轻AD的发展.
TMAO诱导了内皮功能障碍,激活了NF-κB信号传递,并增加了大动脉炎症.

结论:

肠道微生物代谢物TMAO通过诱导内皮功能障碍和炎症来加剧大动脉剖析.
TMAO是一种潜在的风险因素,也是大动脉剖析的治疗点.
这项研究为AD病因学和管理策略提供了新的见解.

关键词:

动脉剖析是一个大动脉剖析.内皮质功能障碍内皮质功能障碍炎症炎症是一种炎症.三甲基胺N-氧化物

更多相关视频

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

Multimodality Diagnosis of Mesenteric Ischemia

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

相关概念视频

Aneurysm I: Introduction

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...