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光盘出血大小在视野进展中的临床意义青光眼中的视野进展

Yoon Jeong¹, Eunoo Bak², Mirinae Jang³

¹From the Department of Ophthalmology (Y.J., Y.S., M.G.H., Y.K.K., J.W.J., K.H.P.), Seoul National University Hospital, Seoul, Korea.

American journal of ophthalmology

|February 23, 2024

概括

在开角玻璃眼 (OAG) 患者中,较大的光盘出血 (DH) 尺寸与更快的视野恶化有关. 这一发现突显了DH大小作为眼病进展的重要预测因素.

科学领域:

眼科医生眼科眼科
玻璃眼研究研究玻璃眼研究
视神经头部成像视神经头部成像

背景情况:

光盘出血 (DH) 是一种已知的青光眼进展的指标.
了解DH大小和疾病严重程度之间的关系对于患者管理至关重要.

研究的目的:

为了研究光盘出血 (DH) 的大小与开角玻璃眼 (OAG) 患者的玻璃眼进展率之间的相关性.
为了确定DH大小作为视野 (VF) 恶化的潜在预测因素.

主要方法:

对250名患有肝炎的OAG患者进行了回顾性观察队列研究,至少5年跟踪至少5次视野 (VF) 测试.
光盘出血 (DH) 区域使用光学连贯性断层扫描 (OCT) 来量化.
平均偏差 (MD) 损失率使用指导性进展分析 (GPA) 进行评估,并进行回归分析以确定MD损失的预测因素.

主要成果:

与小DH患者相比,大DH患者的全球平均偏差 (MD) 损失明显更快 (-0.51±0.48 dB/y对比 -0.36 ±0.42 dB/y,P = .01).
多变量回归分析显示,平均DH大小,最大DH大小和初始MD都与MD损失的总比率有显著的相关性 (所有P<0.05).

结论:

光盘出血 (DH) 尺寸与视野 (VF) 恶化的速度在开角玻璃眼 (OAG) 患者中显著相关.
较大的DH表明明显VF进展的风险更高,强调其在监测玻璃眼的临床重要性.

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