一个快速的程序来评估在康复过程中对饮酒的歧视性控制的转变,类似于恢复行为
Acacia Nawrocik-Madrid1, Hanana AlTfaili1, R J Lamb1
1Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States.
Alcohol (Fayetteville, N.Y.)
|February 23, 2024
概括
较长的恢复期减少了老鼠对饮酒的刺激控制,可能会增强复发抵抗力. 这项研究开发了一种更快的方法来观察恢复期间刺激控制中的这些变化.
科学领域:
- 行为神经科学 行为神经科学
- 成研究研究成研究
背景情况:
- 以前的研究表明,类似恢复的行为减少了对饮酒的刺激控制,与增加的复发抵抗性相关.
- 以前的研究由于程序限制而缺乏纵向分析.
- 这项研究旨在通过更有效的程序,复制并将发现扩展到雌性大鼠.
研究的目的:
- 开发一种有效的方法来评估在康复期间饮酒对刺激控制的变化.
- 研究恢复对大鼠刺激控制的纵向影响.
- 为了将以前的发现扩展到雌性大鼠.
主要方法:
- 鼠被训练在多个并发的时间表以乙醇或食物增强.
- 饮酒阶段之后是恢复阶段,其中与乙醇相关的刺激物被呈现为灭绝.
- 在暴露于乙醇刺激的过程中,对食物的反应在多次会议中进行了测量.
主要成果:
- 在乙醇测试期间,食物反应的数量随着恢复会议的增加而增加,这与之前的研究结果一致.
- 刺激方式 (视觉或听觉) 并没有显著改变这种关系.
- 长时间的酒精暴露和性行为没有产生显著的影响.
结论:
- 一个快速的程序证实,更长的恢复期减少了对饮酒的刺激控制.
- 这种刺激控制的减少与临床观察增加复发抵抗的临床观察一致.
- 刺激类型,饮酒史持续时间和性别在测试条件下没有影响这种观察到的关系.
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