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剧烈的压力增加了与皮区域的皮连接,这些区域富含了μ和k片受体
Peter Zhukovsky1, Maria Ironside2, Jessica M Duda1
1Center for Depression, Anxiety and Stress Research, Department of Psychiatry, McLean Hospital, Harvard Medical School, Boston, Massachusetts.
Biological psychiatry
|February 23, 2024
概括
急性压力显著改变大脑连接,影响对情绪调节至关重要的网络. 这些变化与特定的基因表达和与主要抑郁症 (MDD) 相关的受体通路有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 了解压力的神经生物学基础对于破译主要抑郁症 (MDD) 的病因至关重要.
- 这项研究采用了一种维度方法,检查了不同程度的MDD风险的个体,以调查压力诱导的大脑连接的改变.
研究的目的:
- 调查急性压力对皮层-皮层和皮层下皮层功能连接 (FC) 的影响.
- 探索压力诱导的FC变化,基因表达模式和受体分布之间的关系.
主要方法:
- 在蒙特利尔成像压力任务期间,对115名参与者 (对照组,转移的MDD,当前的MDD) 进行了功能连接 (FC) 评估.
- 部分最小平方回归在艾伦人类大脑图谱中确定了与与压力相关的FC变化相关的基因.
- 与压力相关的FC图与通过正子发射断层扫描获得的阿片类和胺黄油酸A (GABAA) 受体分布图相关.
主要成果:
- 急性压力导致全球皮质连接的显著变化,在前端对象和注意网络中增加了FC,而在中间默认模式网络中降低了FC.
- 在纹状区域 (尾骨,骨,杏仁体) 和涉及注意力,执行功能和运动控制的网络之间,FC增加.
- 这些区域表现出与细胞间信号传递相关的基因的偏好表达 (例如,OPRM1,GABRA3),与之前的MDD遗传研究一致.
结论:
- 急性压力调节全球皮层和条纹连接,将应激反应电路与MDD相关的途径联系起来.
- 观察到的连接性变化与以前与MDD相关的基因表达模式和受体配置文件 (μ和 κ阿片类受体) 有关.
- 研究结果表明,重叠的神经回路调解压力反应,奖励处理和主要抑郁症的病理生理学.
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